EuroMRD ALL 2026

EuroMRD ALL EQA scheme 2026

Task 1-3: IG/TR-based RQ-PCR

Within these tasks, quality assessment for IG/TR based minimal residual disease (MRD) RQ-PCR for acute lymphoblastic leukemia (ALL) is performed. Task 1 deals with correct interpretation of IG/TR RQ-PCR based on real-time quantitative PCR data of 10 patient cases presented as electronic files. Task 2 consists of IG/TR target detection and sequence analysis in a diagnostic sample and subsequent quantification of MRD in follow-up (FU) samples. Task 3 includes analysis of provided IG/TR sequences and RQ-PCR based MRD quantification in FU samples.

Always combined with the mandatory Task 1, Task 2 is issued for the spring and Task 3 for the autumn EQA round.

Performance evaluation and report

Certificates of participation and performance in EQA rounds will be distributed after the EuroMRD meeting of the same calendar year. Performance criteria of the ALL scheme: a certificate will be provided if at least 75% of points have been received (spring round: Tasks 1 & 2; Autumn round: Tasks 1 & 3), otherwise only a certificate of attendance will be provided for the respective tasks.

After release of the certificates, participants can submit an appeal if they feel that a mistake was made in the assessment of their performance. If applicable, certificates will be adapted based on received appeals.

EQA Educational meeting

During the ESLHO week in November, the annual EuroMRD meeting is organized. At this meeting, the results of all EuroMRD EQA schemes are shown (pseudonymized) and discussed with all EuroMRD participants, in small discussion groups as well as during plenary sessions.

Registration and participation fee

The EuroMRD ALL EQA scheme is only available for participants of the EuroMRD Consortium that are part of the ALL section. The participation fee is € 300 for both rounds (it is not possible to register for only one round of this scheme). In addition, the EuroMRD annual fee is charged once to every EuroMRD participant.

Organization

The ALL EQA scheme is organized by ESLHO (EQA Program Coordinator: Prof. Dr. Jacques J.M. van Dongen) in collaboration with the EuroMRD EQA Committee (ALL scheme lead: Prof. Dr. Monika Brüggemann). The members of the EuroMRD EQA Committee are participants of the EuroMRD Consortium. The EuroMRD subject-matter experts provide support for:

• Pre-round: Case selection, determination of consensus results

• Post-round: Data analysis, performance evaluation, reporting

Details on the task division can be found below.

Task division